Neurotransmitter release from hair cells and its blockade by glutamate-receptor antagonists
Identifieur interne : 001624 ( Main/Exploration ); précédent : 001623; suivant : 001625Neurotransmitter release from hair cells and its blockade by glutamate-receptor antagonists
Auteurs : Philip A. Starr [États-Unis] ; William F. Sewell [États-Unis]Source :
- Hearing Research [ 0378-5955 ] ; 1990.
Abstract
To assess the mechanism by which glutamate-receptor antagonists block afferent discharge at the hair cell synapse, we examined the effects of these and other agents on sound-evoked excitatory post-synaptic potentials (EPSPs) and on spontaneous miniature post-synaptic potentials (MEPSPs) in auditory-nerve fibers of the goldfish (Carassius auratus) saccule. A quantal analysis of synaptic transmission under conditions in which the probability of transmitter release was reduced by cobalt, an agent that can block transmitter release, supports Furukawa's (Jpn. J. Physiol. 36, 1059–1077, 1986) conclusion that transmitter release at this synapse is quantal. Cobalt reduced the rate of occurrence of spontaneous MEPSPS without reducing their amplitude. The glutamate-receptor antagonists, gamma-d-glutamyl glycine (DGG) and 5-aminophosphonovaleric acid (APV) both reduced the amplitude of soundevoked EPSPs much more than that of the spontaneous MEPSPs. The glutamate-receptor agonists, l-glutamate, kainate, and quisqualate, produced a depolarization of the afferent nerve fiber, a decrease in the amplitude of the EPSP and an increased tendency for an EPSP to generate an action potential.
Url:
DOI: 10.1016/0378-5955(91)90185-C
Affiliations:
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Starr</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary and the Department of Otolaryngology and the Program in Neuroscience, Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sewell, William F" sort="Sewell, William F" uniqKey="Sewell W" first="William F." last="Sewell">William F. Sewell</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary and the Department of Otolaryngology and the Program in Neuroscience, Harvard Medical School, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Hearing Research</title><title level="j" type="abbrev">HEARES</title><idno type="ISSN">0378-5955</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">52</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="23">23</biblScope><biblScope unit="page" to="41">41</biblScope></imprint><idno type="ISSN">0378-5955</idno></series><idno type="istex">BF7263E0AFDB651B9848AA5056FD38D24D775B6B</idno><idno type="DOI">10.1016/0378-5955(91)90185-C</idno><idno type="PII">0378-5955(91)90185-C</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-5955</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the mechanism by which glutamate-receptor antagonists block afferent discharge at the hair cell synapse, we examined the effects of these and other agents on sound-evoked excitatory post-synaptic potentials (EPSPs) and on spontaneous miniature post-synaptic potentials (MEPSPs) in auditory-nerve fibers of the goldfish (Carassius auratus) saccule. A quantal analysis of synaptic transmission under conditions in which the probability of transmitter release was reduced by cobalt, an agent that can block transmitter release, supports Furukawa's (Jpn. J. Physiol. 36, 1059–1077, 1986) conclusion that transmitter release at this synapse is quantal. Cobalt reduced the rate of occurrence of spontaneous MEPSPS without reducing their amplitude. The glutamate-receptor antagonists, gamma-d-glutamyl glycine (DGG) and 5-aminophosphonovaleric acid (APV) both reduced the amplitude of soundevoked EPSPs much more than that of the spontaneous MEPSPs. The glutamate-receptor agonists, l-glutamate, kainate, and quisqualate, produced a depolarization of the afferent nerve fiber, a decrease in the amplitude of the EPSP and an increased tendency for an EPSP to generate an action potential.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Boston</li></settlement></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Starr, Philip A" sort="Starr, Philip A" uniqKey="Starr P" first="Philip A." last="Starr">Philip A. Starr</name></region><name sortKey="Sewell, William F" sort="Sewell, William F" uniqKey="Sewell W" first="William F." last="Sewell">William F. Sewell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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